Interspecies extrapolation of pharmacoki
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Curtis C. Travis; Robin K. White; Richard C. Ward
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Article
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1990
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Elsevier Science
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English
β 1020 KB
The purpose of this paper is to use physiologically based pharmacokinetic models to demonstrate that if toxic response is a function of the time profile in physiological time of the concentration of the toxic moiety in the target tissue, then the appropriate interspecies scaling law for toxic compou