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Interspecies Extrapolation of Physiological Pharmacokinetic Parameter Distributions

✍ Scribed by Karen H. Watanabe; Frédéric Y. Bois

Book ID
109157103
Publisher
Springer
Year
1996
Tongue
English
Weight
983 KB
Volume
16
Category
Article
ISSN
1573-9147

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Interspecies extrapolation of pharmacoki
Interspecies extrapolation of pharmacokinetics
✍ Curtis C. Travis; Robin K. White; Richard C. Ward 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 1020 KB

The purpose of this paper is to use physiologically based pharmacokinetic models to demonstrate that if toxic response is a function of the time profile in physiological time of the concentration of the toxic moiety in the target tissue, then the appropriate interspecies scaling law for toxic compou