## BACKGROUND. Accumulation of mutated p53 in malignant cells can lead to the generation of anti-p53 autoantibodies in the serum and other body fluids of cancer patients. This retrospective study was performed to evaluate the prognostic significance of preoperative serum and ascitic anti-p53 antibo
Serum p53 autoantibodies: incidence in ovarian carcinoma
β Scribed by K.A. Angelopoulou; M. Stratis; E.P. Diamandis
- Book ID
- 103041950
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 121 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0009-9120
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The serum copper and CA 125 levels of 31 patients with epithelial ovarian carcinoma were determined. Serum copper was elevated in seven patients and CA 125 was elevated in 22 patients. A rise in serum CA 125 always was associated with disease progression. In comparison, serum copper fluctuation did
## BACKGROUND. Although p53 gene mutation frequently is observed in ovarian carcinoma, the function of the p53 gene in chemosensitivity has not been defined conclusively. The objective of the current study was to elucidate the relation between chemotherapy-induced apoptosis through the p53 pathway