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Clinical significance of serum and ascitic p53 autoantibodies in epithelial ovarian carcinoma

✍ Scribed by Burghard Abendstein; Christian Marth; Elisabeth Müller-Holzner; Martin Widschwendter; Günter Daxenbichler; Alain G. Zeimet

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
83 KB
Volume
88
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Accumulation of mutated p53 in malignant cells can lead to the generation of anti-p53 autoantibodies in the serum and other body fluids of cancer patients. This retrospective study was performed to evaluate the prognostic significance of preoperative serum and ascitic anti-p53 antibodies in advanced ovarian carcinoma.

METHODS.

In 113 ovarian carcinoma patients who presented with significant amounts of ascites, anti-p53 autoantibodies were determined by a highly specific enzyme-linked immunosorbent assay of blood and ascites. Disease free and overall survival of study patients was estimated by the product limit method of Kaplan and Meier. Differences in survival were examined according to criteria of Mantel and Breslow. A multiple regression analysis based on the Cox proportional hazards model was used to determine the independence of prognostic variables.

RESULTS.

Serum and ascitic anti-p53 antibodies were found in 28 (25%) and 21 (19%) of the study patients, respectively. In univariate analysis, detection of anti-p53 antibodies in ascites but not in serum was found to be a sign of unfavorable disease free survival (P Ͻ 0.003) and overall survival (P Ͻ 0.01). Multivariate analysis revealed that anti-p53 positivity in ascites retained independent significance only in the prediction of adverse progression free survival (P Ͻ 0.01).

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