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Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease

✍ Scribed by Nadeeka N.W. Dissanayaka; Peter A. Silburn; John D. O'Sullivan; George D. Mellick

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
438 KB
Volume
24
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. Β© 2008 Movement Disorder Society

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