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Association study of dopamine D2, D3, D4 receptor and serotonin transporter gene polymorphisms with sleep attacks in Parkinson's disease

✍ Scribed by Sebastian Paus; Gert Seeger; Hans M. Brecht; Jürgen Köster; Mahha El-Faddagh; Markus M. Nöthen; Thomas Klockgether; Ullrich Wüllner

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
47 KB
Volume
19
Category
Article
ISSN
0885-3185

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✦ Synopsis

Sleep attacks are a common yet only recently recognized phenomenon in patients with Parkinson's disease (PD). Initially reported to occur only with particular dopamine agonists, sleep attacks have been observed with all dopaminergic drugs. [1][2][3] In the majority of affected patients, sleep attacks are a stable phenomenon and occur with and without excessive daytime sleepiness. 2 Presence or absence of warning signs preceding a sleep attack have received particular interest, as sleep attacks without warning signs might be especially dangerous.

It is conceivable that intrinsic variations of the sleep regulating systems in interaction with dopaminergic drugs may provoke the occurrence of sleep attacks. To test if genetic variants of the different dopamine receptors or the serotonin transporter contribute to the etiology of sleep attacks, we examined four known polymorphisms of the genes for dopamine receptors 2, 3, and 4 (DRD2 141C del/ins; DRD2 TaqIA; DRD3 Ser9Gly; DRD4 48 base pair [bp] repeat), and the 5-HTTLPR polymorphism in the serotonin transporter gene (SERT) in a community based case control study. We found an association between sleep attacks without warning signs and the DRD4*2 (short) allele.

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