Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia
β Scribed by Koenraad Van Doorslaer; Laura L. Reimers; Yevgeniy Y. Studentsov; Mark H. Einstein; Robert D. Burk
- Book ID
- 113962109
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 371 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0090-8258
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Sera from patients with cervical cancer, cervical intraepithelial neoplasia (CIN) and non-genital cancers, and from healthy individuals, were investigated for antibodies to human papilloma virus (HPV) early proteins E4, E6 and E7 and the major capsid protein LI by Western blot analysis of recombinan
## Abstract Persistent infection with human papillomaviruses (HPV) is a prerequisite for the development of cervical cancer. Vaccination with virusβlike particles (VLP) has demonstrated efficacy in prophylaxis but lacks therapeutic potential. HPV16 L1E7 chimeric virusβlike particles (CVLP) consist