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Performance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results

✍ Scribed by Miriam Reuschenbach; Andreas Clad; Christina von Knebel Doeberitz; Nicolas Wentzensen; Janina Rahmsdorf; Frauke Schaffrath; Henrik Griesser; Nikolaus Freudenberg; Magnus von Knebel Doeberitz

Book ID
113962532
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
456 KB
Volume
119
Category
Article
ISSN
0090-8258

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## Abstract p16^INK4a^, a cell cycle regulation protein, accumulates in abnormal epithelial cells infected with high‐risk human papilloma virus (HPV). In immunostaining studies, p16^INK4a^ has shown potential as a marker of high grade cervical intraepithelial neoplasia (CIN) and invasive cervical c