Sequential 5-fluorouracil and leucovorin in patients with advanced symptomatic gastrointestinal cancer
✍ Scribed by Carlsson, Göran; Graf, Wilhelm; Gustavsson, Bengt G.; Glimelius, Bengt; Påhlman, Lars; Spears, Paul C.
- Book ID
- 122822350
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 337 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0277-5379
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## Abstract Forty‐one patients with measurable advanced gastrointestinal malignancy were treated with a combination of Adriamycin (doxorubicin), 5‐FU (5‐fluorouracil), and CCNU (1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea). The response to therapy was evaluated every eight weeks. In addition to st
Extensive preclinical data have demonstrated that leucovorin can modulate 5-fluorouracil (5-FU) cytotoxicity. Additionally, randomized clinical trials have shown that leucovorin increases the therapeutic index of 5-FU in patients with advanced colorectal cancer, setting a new therapeutic standard fo