We report the application of nanoelectrospray ionization tandem mass spectrometry (nES-MS/MS) and capillary LC/microelectrospray MS/MS (cLC/&mgrES-MS/MS) for sequencing sulfonic acid derivatized tryptic peptides. These derivatives were specifically prepared to facilitate low-energy charge-site-initi
Sequencing of Argentinated Peptides by Means of Electrospray Tandem Mass Spectrometry
β Scribed by Chu, Ivan K.; Guo, Xu; Lau, Tai-Chu; Siu, K. W. Michael
- Book ID
- 121866150
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 133 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0003-2700
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The collision-induced decomposition spectra of electrospray-produced molecule ions were investigated on a hybrid tandem mass spectrometer. The molecular mass of the peptides investigated ranged from m/z 409 (as the singly protonated molcule ion) to 1758 (as the singly, doubly and triply protonated m
## Abstract In this research, the characteristic ions' abundance ratio between two isomers A and B in MS/MS mass spectra was defined as a parameter for discriminating diastereomers. Through this ratio, the discrimination of four pairs of cyclic peptide (CP) diastereomers was successfully achieved.