Separation strategy for acidic chiral pharmaceuticals with capillary electrochromatography on polysaccharide stationary phases
โ Scribed by Debby Mangelings; Indiana Tanret; Nele Matthijs; Mohamed Maftouh; D. Luc Massart; Yvan Vander Heyden
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 527 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0173-0835
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๐ SIMILAR VOLUMES
New chiral stationary phases of polydimethylsiloxane anchored with (S)-(ร)-t-leucine derivatives were provided for use in enantiomer separation of pharmaceuticals by capillary gas chromatography. Fifteen pharmaceuticals were separated into their enantiomeric pairs by converting them into pentafluoro
## Abstract A generic strategy for the chiral separation of nonโacidic pharmaceuticals was updated to complete an approach defined earlier. The selected chiral stationary phases are all polysaccharide selectors, chlorinated, and nonโchlorinated, namely Lux^ยฎ^ Amylose 2, Chiralcel^ยฎ^ ODโRH, Lux^ยฎ^ C