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Separation of potent central and renal dopamine agonist activity in substituted 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepines

โœ Scribed by Weinstock, Joseph; Wilson, James W.; Ladd, David L.; Brush, Charles K.; Pfeiffer, Francis R.; Kuo, George Y.; Holden, Kenneth G.; Yim, Nelson C. F.; Hahn, Richard A.


Book ID
126023196
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
369 KB
Volume
23
Category
Article
ISSN
0022-2623

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Radiosynthesis of a selective dopamine D
โœ Hayden T. Ravert; Alan A. Wilson; Robert F. Dannals; Dean F. Wong; Henry N. Wagn ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science โš– 200 KB

Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was compl