Different drug stereoisomers can have different physiological and therapeutic effects. Difficulties in separating optical isomers often make it impractical to market stereochemically pure products or to monitor isomeric contamination. This is not thought to be a problem with drugs isolated from biol
Separation of optical isomere of scopolamine cocaine, homatropine, and atropine
β Scribed by Armstrong, DW; Han, SM; Han, YI
- Book ID
- 122977407
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 87 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0378-8741
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The purpose of this study was to develop a procedure for the quantitative analysis of the salts of the solanaceous alkaloids in the presence of their hydrolysis products. The salts taken were atropine sulfate, homatropine hydrobromide, homatropine methylbromide, scopolamine hydrobromide, and scopola
Separation of optical isomeric drugs using micellar electrokinetic chromatography and bile salts as surfactants was studied. Optical isomers of diltiazem hydrochloride, trimetoquinol hydrochloride, and other drugs were separated successfully using chiral bile salts under neutral or alkaline conditio
## Abstract To isolate atropine and scopolamine from __Daturae metelis Flos__, three different elution modes have been applied in pHβzoneβrefining counterβcurrent chromatography. These separations were performed with a twoβphase solvent system composed of ethyl acetate/__n__βbutanol/water (4:1:5βv/