Colorimetric determination of atropine, homatropine, scopolamine, and their derivatives by the ferric hydroxamate method
✍ Scribed by Joseph A. Feldman; Bruce J. Robb
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 256 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
The purpose of this study was to develop a procedure for the quantitative analysis of the salts of the solanaceous alkaloids in the presence of their hydrolysis products. The salts taken were atropine sulfate, homatropine hydrobromide, homatropine methylbromide, scopolamine hydrobromide, and scopolamine methylbromide. The ferric hydroxamate procedure was used. The conditions necessary for a reproducible reaction were established; a procedure of sufficient sensitivity was developed which will allow unit dose analysis; and an analysis was developed which will permit the salts of the solanaceous alkaloids to be quantitatively analyzed in the presence of their degradation products.