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Separation of human pepsin and gastricsin by affinity chromatography with an immobilized synthetic inhibitor

✍ Scribed by Z. Kucˇerova´; J. Pohl; L. Korbova´

Book ID
108447903
Publisher
Elsevier Science
Year
1986
Weight
528 KB
Volume
376
Category
Article
ISSN
0378-4347

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✍ Jan Pohl; Milan Zaoral; Antonín Jindra Jr.; Vladimír Kostka 📂 Article 📅 1984 🏛 Elsevier Science 🌐 English ⚖ 759 KB

Val-D-Leu-Pro-Phe-Phe-Val-D-Leu, a specific inhibitor of aspartate proteinases of the pepsin type, was synthesized. Its bonding to activated 6-aminohexanoic acid-Sepharose 4B afforded an affinity support suitable for the purification of human, porcine, and chicken pepsin, human gastricsin, and bovin