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Separation of 11 protease and reverse transcriptase inhibitors by capillary zone electrophoresis

✍ Scribed by Wolfgang Gutleben; Karin Scherer; Nguyen Duc Tuan; Heribert Stoiber; Manfred P. Dierich; Andreas Zemann

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
651 KB
Volume
26
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

Capillary zone electrophoresis is employed for the simultaneous screening of protease and reverse transcriptase inhibitors which are used as antiretroviral therapy drugs against the Human Immunodeficiency Virus. Because of the basic character of the analytes, the electrophoretic system makes use of an acidic buffer electrolyte. In order to establish a strong anodic electroosmotic flow, a cationic surfactant is added to the background electrolyte. This causes the cationic analytes to migrate against the electroosmotic stream (counter‐electroosmotic CE). The developed separation system permits a simultaneous separation of protease and reverse transcriptase inhibitors with good selectivity and sensitivity.

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Separation of phosphorylated nucleoside
Separation of phosphorylated nucleoside reverse transcriptase inhibitors by capillary electrophoresis
✍ Melissa N. Dunkle; Jill Hochreister; Robin DiFrancesco; Gene D. Morse; Luis A. C πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 English βš– 335 KB

Capillary electrophoretic (CE) conditions were established to separate multiple nucleoside reverse transcriptase inhibitor triphosphates (NRTI-TPs). These are the active drug forms of nucleoside reverse transcriptase inhibitors (NRTIs) used to treat HIV-infected patients and two NRTIs are always use