We tested the effectiveness of dihydroxyanthracenedione (DHAD) on cell growth of two human pancreatic carcinoma cell lines MIA PaCa-2 and PANC-1. At the level of ID,,, the drug was almost equally effective against both cell lines. When the time exposure of MIA PaCa-2 cells to the drug was increased
Sensitivity of rat pancreatic A and B cells to somatostatin
β Scribed by F. C. Schuit; M. -P. Derde; D. G. Pipeleers
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 662 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0012-186X
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Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.
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