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Morphological and functional changes of pancreatic B cells in cyclosporin A-treated rats

โœ Scribed by U. Helmchen; W. E. Schmidt; E. G. Siegel; W. Creutzfeldt

Publisher
Springer
Year
1984
Tongue
English
Weight
695 KB
Volume
27
Category
Article
ISSN
0012-186X

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โœฆ Synopsis

Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.

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