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Reversibility of the acute toxic effect of Cyclosporin A on pancreatic B cells of Wistar rats

โœ Scribed by H. -J. Hahn; A. Dunger; F. Laube; W. Besch; E. Radloff; C. Kauert; G. Kotzke

Publisher
Springer
Year
1986
Tongue
English
Weight
583 KB
Volume
29
Category
Article
ISSN
0012-186X

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Our objective was to examine the effect of cyclosporin A (CsA; 25 or 12.5 mg/kg) on growth of an acute (Roser) T-cell leukaemia in male PVG rats. The leukaemic blasts were shown (by immunocytochemical analysis) to have a mature, T-helpercell phenotype, Le., OX-I9 (CD5)\*, W3/25 (CD4)+, OX44+, MHC-cl