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Sensitive assay for determination of hydroxyzine in plasma and its human pharmacokinetics

✍ Scribed by Hassan G. Fouda; Donald C. Hobbs; John E. Stambaugh

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
324 KB
Volume
68
Category
Article
ISSN
0022-3549

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✦ Synopsis

An assay suitable for hydroxyzine determination in human plasma following therapeutic doses was developed. The method involves GLC and chemical-ionization mass spectrometry of the acetate derivatives of hydroxyzine and of a pentadeuterated analog internal standard. Following administration of 100-mg single oral doses to normal male volunteers, peak plasma concentrations of approximately 80 ng/ml were observed; the half-life of drug removal was approximately 3 hr.

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