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Semisynthesis of human thymidine monophosphate kinase

✍ Scribed by Lars Gogolin; Ralf Seidel; Martin Engelhard; Roger S. Goody; Christian F. W. Becker

Publisher
Wiley (John Wiley & Sons)
Year
2010
Tongue
English
Weight
898 KB
Volume
94
Category
Article
ISSN
0006-3525

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## Abstract __Mycobacterium tuberculosis__ thymidine monophosphate kinase (TMPKmt) has recently been introduced as a potential target for the structure‐based design of anti‐tuberculosis drugs. Based on the TMPKmt X‐ray structure and previous S.A.R. studies, we synthesised the nucleoside analogues *