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Selective Protection of 2‘,2‘-Difluorodeoxycytidine (Gemcitabine)

✍ Scribed by Guo, Zhi-wei; Gallo, James M.


Book ID
120508776
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
91 KB
Volume
64
Category
Article
ISSN
0022-3263

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✍ J. Haveman; R. C. Rietbroek; A. Geerdink; J. van Rijn; P. J. M. Barker 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 452 KB

Difluorodeoxycitidine (dFdCyd. gemcitabine) was tested for cytotoxicity in cultured human lung-cancer cells SW I573 in combination with I hr hyperthermia at 43'C. The results show that the timing is extremely important. Simultaneous application led to decreased cytotoxicity, whereas an interval of 2