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Clinical and preclinical activity of 2′,2′- difluorodeoxycytidine (gemcitabine)

✍ Scribed by Lund, Birthe; Kristjansen, Paul E.G.; Hansen, Heine H.


Book ID
122906297
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
769 KB
Volume
19
Category
Article
ISSN
0305-7372

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Effect of hyperthermia on the cytotoxici
✍ J. Haveman; R. C. Rietbroek; A. Geerdink; J. van Rijn; P. J. M. Barker 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 452 KB

Difluorodeoxycitidine (dFdCyd. gemcitabine) was tested for cytotoxicity in cultured human lung-cancer cells SW I573 in combination with I hr hyperthermia at 43'C. The results show that the timing is extremely important. Simultaneous application led to decreased cytotoxicity, whereas an interval of 2