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Effect of hyperthermia on the cytotoxicity of 2′,2′-difluorodeoxycytidine (gemcitabine) in cultured SW1573 cells

✍ Scribed by J. Haveman; R. C. Rietbroek; A. Geerdink; J. van Rijn; P. J. M. Barker

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
452 KB
Volume
62
Category
Article
ISSN
0020-7136

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✦ Synopsis

Difluorodeoxycitidine (dFdCyd. gemcitabine) was tested for cytotoxicity in cultured human lung-cancer cells SW I573 in combination with I hr hyperthermia at 43'C. The results show that the timing is extremely important. Simultaneous application led to decreased cytotoxicity, whereas an interval of 20 or 24 hr between exposure to dFdCyd and hyperthermia led to enhanced cell killing. The decrease in cytotoxicity after simultaneous hyperthermia and dFdCyd probably results from inhibition of activation of dFdCyd to the triphosphate metabolite.

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