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Selective nitrolytic deprotection of N-BOC-amines and N-BOC-amino acids derivatives

✍ Scribed by Paolo Strazzolini; Tiziana Melloni; Angelo G Giumanini

Book ID
108371380
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
182 KB
Volume
57
Category
Article
ISSN
0040-4020

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A mild and selective method for N-Boc de
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✍ Sylvain Routier; Laurence SaugΓ©; Nathalie Ayerbe; GΓ©rard Coudert; Jean-Yves MΓ©ro πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 126 KB

A new mild method to remove N-tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding N-free products are obtained in good yields. The reactions are selective for acid-and base-sensitive groups, such as tert-butyl and alkyl esters, aldehydes.