A mild and selective method for N-Boc deprotection

✍ Scribed by Sylvain Routier; Laurence Saugé; Nathalie Ayerbe; Gérard Coudert; Jean-Yves Mérour

• Book ID: 104232266
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 126 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02225-0

✦ Synopsis

A new mild method to remove N-tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding N-free products are obtained in good yields. The reactions are selective for acid-and base-sensitive groups, such as tert-butyl and alkyl esters, aldehydes.