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Boiling water-catalyzed neutral and selective N-Boc deprotection

✍ Scribed by Wang, Jia; Liang, Yan-Liang; Qu, Jin

Book ID
118131431
Publisher
Royal Society of Chemistry
Year
2009
Tongue
English
Weight
575 KB
Volume
34
Category
Article
ISSN
1359-7345

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A mild and selective method for N-Boc de
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✍ Sylvain Routier; Laurence SaugΓ©; Nathalie Ayerbe; GΓ©rard Coudert; Jean-Yves MΓ©ro πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 126 KB

A new mild method to remove N-tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding N-free products are obtained in good yields. The reactions are selective for acid-and base-sensitive groups, such as tert-butyl and alkyl esters, aldehydes.