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Selective neurotoxicity of COOH-terminal fragments of the β-amyloid precursor protein

✍ Scribed by Fukuchi, Ken-ichiro; Sopher, Bryce; Furlong, Clement E.; Smith, Annette C.; Dang, NgocThao; Martin, George M.

Book ID
121969828
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
421 KB
Volume
154
Category
Article
ISSN
0304-3940

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## Abstract The AICD (APP intracellular Domain) and C31, caspase‐cleaved C‐terminal fragment of APP, have been found in Alzheimer's disease (AD) patients' brains and have been reported to induce apoptosis in neuronal cells. In recent, the C‐terminal fragments of amyloid precursor protein (APP‐CTs)