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Selective localisation of radiolabelled monoclonal antibodies to human neuroblastoma xenografts in a nude mouse model

Book ID
122962020
Publisher
Elsevier Science
Year
1982
Weight
174 KB
Volume
18
Category
Article
ISSN
0277-5379

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Therapeutic application of a radiolabell
Therapeutic application of a radiolabelled monoclonal antibody in nude mice xenografted with human neuroblastoma: Tumoricidal effects and distribution studies
โœ D. H. Jones; A. Goldman; I. Gordon; J. Pritchard; B. J. Gregory; J. T. Kemshead ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 568 KB

## Abstract Monoclonal antibody UJ13A radiolabelled with isotopes of iodine has been shown to selectively localize to human neuroblastoma xenografts. When ^131^Iโ€UJ13A conjugates were given to nude mice at high doses (100โ€“150 ฮผCi), tumours temporarily disappeared, only to regrow. No selection for n