Therapeutic effect of a radiolabeled monoclonal antibody on human ovarian cancer xenograft in nude mice
โ Scribed by Alberto Manetta; Pondichery G. Satyaswaroop; Thomas Hamilton; Robert Ozols; Rodrigue Mortel
- Book ID
- 119053237
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 273 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0090-8258
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๐ SIMILAR VOLUMES
## Abstract Monoclonal antibody UJ13A radiolabelled with isotopes of iodine has been shown to selectively localize to human neuroblastoma xenografts. When ^131^IโUJ13A conjugates were given to nude mice at high doses (100โ150 ฮผCi), tumours temporarily disappeared, only to regrow. No selection for n
The biodistribution and pharmacokinetics of 2 monoclonal antibodies (MAbs) specific for ovarian carcinoma, O C I25 and OV-TL3, were studied in nude mice bearing intraperitoneally (i.p.) growing human ovarian carcinoma xenografts of NIH:OVCAR-3. The ovarian carcinoma xenografts grew as non-adherent c