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Selective JAK1 inhibitor and selective Tyk2 inhibitor patents

โœ Scribed by Norman, Peter

Book ID
115497360
Publisher
Informa plc
Year
2012
Tongue
English
Weight
904 KB
Volume
22
Category
Article
ISSN
1354-3776

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Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3
โœ Jeremiah P. Malerich; Jennifer S. Lam; Barry Hart; Richard M. Fine; Boris Kleban ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 781 KB

Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.