Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3

✍ Scribed by Jeremiah P. Malerich; Jennifer S. Lam; Barry Hart; Richard M. Fine; Boris Klebansky; Mary J. Tanga; Annalisa D’Andrea

• Book ID: 104004993
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 781 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.10.026

✦ Synopsis

Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.