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Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings

โœ Scribed by Yu, Violeta; Pistillo, Jeanne; Archibeque, Ivonne; Han Lee, Josie; Sun, Bee-Chun; Schenkel, Laurie B.; Geuns-Meyer, Stephanie; Liu, Liqin; Emkey, Renee

Book ID
122551670
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
619 KB
Volume
41
Category
Article
ISSN
0301-472X

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Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.