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Selective irreversible inhibition of mammalian histidine decarboxylase by α-chloromethyl histidine

✍ Scribed by B. Lippert; P. Bey; V. an Dorsselaer; J. P. Vevert; C. Danzin; G. Ribereau-Gayon; M. J. Jung

Publisher
SP Birkhäuser Verlag Basel
Year
1979
Tongue
English
Weight
175 KB
Volume
9
Category
Article
ISSN
1420-908X

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The irreversible inhibition of histidine ammonia lyase by L-cysteine and dioxygen has been reexamined. After denaturation and consecutive digestion of the inhibited enzyme by trypsin and endoproteinase Glu-C, the generated chromophoric system (lambda max = 340 nm) remained intact and was isolated in