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Selective Hydroxylation of a Steroid at C-9 by an Artificial Cytochrome P-450

โœ Scribed by Jerry Yang; Ronald Breslow

Book ID
101371921
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
299 KB
Volume
39
Category
Article
ISSN
0044-8249

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๐Ÿ“œ SIMILAR VOLUMES

Catalytic hydroxylation of steroids by c
Catalytic hydroxylation of steroids by cytochrome P-450 mimics. Hydroxylation at C-9 with novel catalysts and steroid substrates
โœ Ronald Breslow; Jiaming Yan; Sandro Belvedere ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 76 KB

Double binding of a steroid substrate to our previously described mimic of the cytochrome P-450 enzymes hydroxylates carbon 9 of the steroid, but with a second significant product. The geometry has been adjusted with new catalysts that show high selectivity and excellent turnover for the C-9 hydroxy