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Selective Catalytic Hydroxylation of a Steroid by an Artificial Cytochrome P-450 Enzyme

✍ Scribed by Breslow, Ronald; Zhang, Xiaojun; Huang, Ying

Book ID
126814868
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
61 KB
Volume
119
Category
Article
ISSN
0002-7863

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Catalytic hydroxylation of steroids by c
Catalytic hydroxylation of steroids by cytochrome P-450 mimics. Hydroxylation at C-9 with novel catalysts and steroid substrates
✍ Ronald Breslow; Jiaming Yan; Sandro Belvedere πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 76 KB

Double binding of a steroid substrate to our previously described mimic of the cytochrome P-450 enzymes hydroxylates carbon 9 of the steroid, but with a second significant product. The geometry has been adjusted with new catalysts that show high selectivity and excellent turnover for the C-9 hydroxy