Catalytic hydroxylation of steroids by cytochrome P-450 mimics. Hydroxylation at C-9 with novel catalysts and steroid substrates

✍ Scribed by Ronald Breslow; Jiaming Yan; Sandro Belvedere

• Book ID: 104232183
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 76 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02142-6

✦ Synopsis

Double binding of a steroid substrate to our previously described mimic of the cytochrome P-450 enzymes hydroxylates carbon 9 of the steroid, but with a second significant product. The geometry has been adjusted with new catalysts that show high selectivity and excellent turnover for the C-9 hydroxylation.