𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Selective enzymatic acylation of 10-Deacetylbaccatin III

✍ Scribed by Donghyun Lee; Kyung-Chul Kim; Mahn-Joo Kim


Book ID
108387174
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
232 KB
Volume
39
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Lanthanide trifluoromethanesulfonate cat
✍ Eric W.P Damen; Lesly Braamer; Hans W Scheeren πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 100 KB

The selective C-10 acylation of 10-deacetylbaccatin III to baccatin III and derivatives is very efficiently catalysed by lanthanide trifluoromethanesulfonates. Baccatin III, now readily available through this procedure, is an important precursor for an economically viable semisynthesis of paclitaxel

Methyleniminium salts as acylating agent
✍ Christelle Cravallee; Eric Didier; Pascal Pecquet πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 260 KB

New methylenimim'mrt salts were investigated as acylating agent of 10-deneetylbaecatin Ill. Thus, syntla~is of baeeatin llI was performed in one step with 79% isolated yield and 98% selectivity using the iminium salt prepared from mesyl chloride and N-ethyl~de.