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Lanthanide trifluoromethanesulfonate catalysed selective acylation of 10-deacetylbaccatin III

✍ Scribed by Eric W.P Damen; Lesly Braamer; Hans W Scheeren

Book ID
104259665
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
100 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The selective C-10 acylation of 10-deacetylbaccatin III to baccatin III and derivatives is very efficiently catalysed by lanthanide trifluoromethanesulfonates. Baccatin III, now readily available through this procedure, is an important precursor for an economically viable semisynthesis of paclitaxel and its derivatives.

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