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Methyleniminium salts as acylating agent — one step synthesis of baccatin III from 10-deacetylbaccatin III with high selectivity

✍ Scribed by Christelle Cravallee; Eric Didier; Pascal Pecquet


Book ID
104259289
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
260 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis


New methylenimim'mrt salts were investigated as acylating agent of 10-deneetylbaecatin Ill. Thus, syntla~is of baeeatin llI was performed in one step with 79% isolated yield and 98% selectivity using the iminium salt prepared from mesyl chloride and N-ethyl~de.