Selective determination of tolbutamide in pharmaceutical dosage forms by reaction with ninhydrin

✍ Scribed by K. K. Kaistha; W. N. French

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: English
• Weight: 717 KB
• Volume: 57
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600570319

✦ Synopsis

solution of a-(carboxamidino)methanethiolsulfuric acid (1) (10.0 Gm., 0.059 mole) in 6 N hydrochloric acid (250 ml.) was heated at 96" for 17 hr. The reaction mixture was evaporated zn vacuo and the yellow gummy residue recrystallized from 50% aqueous alcohol (4.5 Gm., 550/,), m.p. 22.5-227" dec.; infrared,l 1700 cm.-' (Y C=Nf); NMR