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Selective degradation of oxidatively modified protein substrates by the proteasome

โœ Scribed by Tilman Grune; Katrin Merker; Grit Sandig; Kelvin J.A. Davies


Book ID
117053921
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
232 KB
Volume
305
Category
Article
ISSN
0006-291X

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โœ Tobias Jung; Tilman Grune ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 277 KB

## Abstract The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidi