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Selective benzoylation of primary amines in the presence of secondary amines

✍ Scribed by Tao Wang; Zhongxing Zhang; Nicholas A. Meanwell

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
120 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Compounds containing both primary and secondary amine moieties in the same molecule were treated sequentially with two equivalents of n-butyllithium at room temperature, two equivalents of TMSCI, one equivalent of nbutyllithium and one equivalent of benzoyl chloride, to afford mono-benzoylated diamines. Under these conditions, the primary amine moiety was selectively benzoylated.

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