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Selective arylation of 2-substituted indoles towards 1,2- and 2,3-functional indoles directed through the catalytic system

✍ Scribed by Laurent Djakovitch; Pascal Rouge; Rabah Zaidi


Book ID
119215900
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
293 KB
Volume
8
Category
Article
ISSN
1566-7367

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## Abstract Ketene generated from acetyl chloride or chloroacetyl chloride adds on indolyl Schiff's base double bond to afford 1‐butyl‐3‐substituted‐4‐(2‐aryl‐1__H__‐indol‐3‐yl)‐2‐azetidinones in THF. The reaction proceeds stereospecifically via concerted __trans__ [2+2] cycloaddition. The synthesi