Temperature-Gradient-Directed NMR Monitoring of a [3 + 3]-Cyclocondensation Reaction Between Alkynone and Ethyl 2-Amino-1 H -indole-3-carboxylate Toward the Synthesis of Pyrimido[1,2- a ]indole Catalyzed by Cs 2 CO 3
โ Scribed by Gauniyal, Harsh M.; Gupta, Sahaj; Sharma, Sudhir K.; Bajpai, Usha
- Book ID
- 120253006
- Publisher
- Taylor and Francis Group
- Year
- 2013
- Tongue
- English
- Weight
- 634 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0039-7911
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๐ SIMILAR VOLUMES
## Abstract Triphenylphosphine (TPP) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of indoleโ3โcarboxaldehydes **1(aโe)**, 1โmethylโ1Hโindoleโ3โcarboxaldehydes **4(aโe)**, and 1โethylโ1Hโindoleโ3โcarboxaldehydes **6(aโe)** with the active methylene compound, t
The enolate of 4-N-(tert-butyloxycarbonyl)aminobutyro-7-lacto~e 9 reacted with 2-bromo-1methylindole-3-carboxaldehyde it, the presence of stannic chloride to give the product of aldol condensation 16. Deprotection and dehydration of the latter with trifluoroacetic' acid and dimethyl sulfide followed