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Selective and Efficient Structural Elaboration of 2-(Trifluoromethyl)quinolinones.

✍ Scribed by Marc Marull; Manfred Schlosser


Publisher
John Wiley and Sons
Year
2003
Weight
235 KB
Volume
34
Category
Article
ISSN
0931-7597

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📜 SIMILAR VOLUMES


Selective and Efficient Structural Elabo
✍ Marc Marull; Manfred Schlosser 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB

## Abstract The acid‐catalyzed cyclization‐condensation between anilines and ethyl 4,4,4‐trifluoroacetoacetate affords 1,4‐dihydro‐2‐trifluoromethyl‐4__H__‐4‐quinolinones (**1**), which can easily be converted into 4‐bromo‐2‐(trifluoromethyl)quinolines. These undergo halogen/metal exchange, generat

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