Selective and Efficient Structural Elabo
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Marc Marull; Manfred Schlosser
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Article
📅
2003
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John Wiley and Sons
🌐
English
⚖ 213 KB
## Abstract The acid‐catalyzed cyclization‐condensation between anilines and ethyl 4,4,4‐trifluoroacetoacetate affords 1,4‐dihydro‐2‐trifluoromethyl‐4__H__‐4‐quinolinones (**1**), which can easily be converted into 4‐bromo‐2‐(trifluoromethyl)quinolines. These undergo halogen/metal exchange, generat