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Selective aflatoxin B1-induced sister chromatid exchanges and cytotoxicity in differentiating B and T lymphocytes in vivo

✍ Scribed by Merle B. Potchinsky; Dr. Stephen E. Bloom

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 723 KB
Volume: 21
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.2850210112

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## Abstract The hepatocarcinogen aflatoxin B~1~ (AFB~1~) is a potent recombinagen but weak mutagen in the yeast __Saccharomyces cerevisiae__. AFB~1~ exposure induces DNA damage‐inducible genes, such as __RAD51__ and those encoding ribonucleotide reductase (RNR), through a __MEC1__ (ATR homolog)‐dep