Selection of recombinant peptides for canine leishmaniasis detection by phage display
✍ Scribed by Juliana Franco Almeida; Guilherme Rocha Lino Souza; Fausto Emíllio Capparelli; Carlos Roberto Prudêncio; Ana Paula Peres Freschi; Rone Cardoso; Flávia Figueira Messias; Luiz Ricardo Goulart
- Book ID
- 116966311
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 83 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0165-2427
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Random peptide libraries displayed on phage are used as a source of peptides for epitope mapping, for the identification of critical amino acids responsible for protein-protein interactions and as leads for the discovery of new therapeutics. Efficient and simple procedures have been devised to selec
Phage antibody-display is rapidly maturing into a very effective tool for antibody generation. The recent development of large primary antibody libraries enables selection of antibodies against most targets in under two weeks and many of these antibodies have relatively high (nanomolar) affinities.