✦ LIBER ✦

Selection of biologically active peptides by phage display of random peptide libraries

✍ Scribed by Riccardo Cortese; Paolo Monaci; Alessandra Luzzago; Claudia Santini; Fabrizia Bartoli; Irene Cortese; Paola Fortugno; Giovanni Galfrè; Alfredo Nicosia; Franco Felici

Book ID: 104361941
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 573 KB
Volume: 7
Category: Article
ISSN: 0958-1669
DOI: 10.1016/s0958-1669(96)80072-3

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✦ Synopsis

Random peptide libraries displayed on phage are used as a source of peptides for epitope mapping, for the identification of critical amino acids responsible for protein-protein interactions and as leads for the discovery of new therapeutics. Efficient and simple procedures have been devised to select peptides binding to purified proteins, to monoclonal and polyclonal antibodies and to cell surfaces in vivo and in vitro.

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