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Secretion of parathyroid hormone-related protein by bovine mammary cellsin vitro

✍ Scribed by Hiroyuki Okada; Floyd L. Schanbacher; Laurie K. McCauley; Charles C. Capen; Michelle T. Weckmann; Thomas J. Rosol

Publisher: Springer
Year: 1994
Tongue: English
Weight: 293 KB
Volume: 12
Category: Article
ISSN: 0914-8779
DOI: 10.1007/bf02375695

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## Abstract Secreted frizzled‐related protein (sFRP)‐1 is a Wnt antagonist that when deleted in mice leads to increased trabecular bone formation in adult animals after 13 weeks of age. Treatment of mice with parathyroid hormone (PTH) also increases trabecular bone formation, and some of the anabol